Quinine: not a safe drug for treating nocturnal leg cramps.
نویسنده
چکیده
منابع مشابه
Meta-analysis of efficacy of quinine for treatment of nocturnal leg cramps in elderly people.
OBJECTIVE To assess quantitatively the efficacy of quinine (as quinine sulphate) compared with placebo in the treatment of nocturnal leg cramps. DESIGN A meta-analysis of six randomised, double blind, crossover trials. SETTING Randomised trials that were available as of April 1994. SUBJECTS A total of 107 general ambulatory patients who suffered from regular nocturnal leg cramps from six ...
متن کاملNocturnal leg cramps in older people.
Nocturnal leg cramps are common in older people. Such cramps are associated with many common diseases and medications. Physiological methods may be useful for preventing cramps in some people, but there have been no controlled trials of these approaches. Quinine is moderately effective in preventing nocturnal leg cramps. However, there are concerns about the risk/benefit ratio with this drug. I...
متن کاملNocturnal leg cramps.
Up to 60 percent of adults report that they have had nocturnal leg cramps. The recurrent, painful tightening usually occurs in the calf muscles and can cause severe insomnia. The exact mechanism is unknown, but the cramps are probably caused by muscle fatigue and nerve dysfunction rather than electrolyte or other abnormalities. Nocturnal leg cramps are associated with vascular disease, lumbar c...
متن کاملQuinine-Induced Disseminated Intravascular Coagulation
Every drug comes with some side effect. It is the benefit/risk ratio that determines the medical use of the drug. Quinine, a known antimalarial drug, has been used for nocturnal leg cramps since the 1930s; it is associated with severe life-threatening hematological and cardiovascular side effects. Disseminated intravascular coagulation (DIC), albeit rare, is a known coagulopathy associated with...
متن کاملStretching before sleep reduces the frequency and severity of nocturnal leg cramps in older adults: a randomised trial.
QUESTION In adults who experience nocturnal leg cramps, does stretching of the calf and hamstring muscles each day just before sleep reduce the frequency and severity of the cramps? DESIGN A randomised trial with concealed allocation and intention-to-treat analysis. PARTICIPANTS Eighty adults aged over 55 years with nocturnal leg cramps who were not being treated with quinine. INTERVENTIO...
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ورودعنوان ژورنال:
- CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
دوره 187 4 شماره
صفحات -
تاریخ انتشار 2015